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Sunday, February 19, 2012
Swedish man survives for months in snowed-in car (Reuters)
[unable to retrieve full-text content]Reuters - A Swedish man was dug out alive after being snowed in to his car on a forest track for two months with no food, police and local media reported on Saturday.
Home as well as Commercial Health and fitness Exercise ...
[unable to retrieve full-text content]Getting into shape and residing in shape using a regular exercise schedule is personal goal for most people.
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Saturday, February 18, 2012
Car Loans After Personal bankruptcy ? How Lengthy Must you Wait ...
The important thing to enhancing credit rating following a personal bankruptcy is repairing credit. You will find other ways to rebuild credit. Included in this are acquiring a brand new charge card, credit line, or automobile loan. Many people think that personal bankruptcy causes it to be impossible to get new credit. However, this isn't true. Actually, several loan companies focus on offering home loan programs to people who've lately filed personal bankruptcy. Getting an auto loan after personal bankruptcy is a terrific way to re-establish credit.
How Lengthy In The Event You Wait?
You will find loan companies who are prepared to grant an auto loan for you one next day of personal bankruptcy. Obviously, you will probably pay an rate of interest a few points greater compared to current average. A greater rate of interest may improve your believed monthly obligations by to . If you're able to afford this increase, acquiring an auto loan is a terrific way to enhance your credit score. You might want to receive the loan from the sub prime loan provider. These loan companies are prepared to negotiate reasonable handles people who've a bad credit score. Evaluating rates provided by on the internet and local auto loan brokers may prove useful. Submit a web-based application, and inside a couple of hrs you'll get a reply from various auto loan companies. Compare their offers and rates, and select the right deal.
Should you don't want to pay for a higher rate of interest to have an auto loan carrying out a personal bankruptcy, consider other techniques for re-creating credit. Acquiring a charge card is perfect. Charge card rates for people who've filed a current personal bankruptcy are very high. However, should you conserve a low balance and remove the balance monthly, you won't need to pay large finance costs. If at all possible, try to obtain a minimum of three new charge cards.
Following the new credit accounts happen to be opened up for six several weeks to 1 year, try to get the auto loan. By this time around, your credit rating may have enhanced. For those who have established a great payment history with new creditors, you might have the ability to get the auto loan in a reasonable rate. A great payment history includes zero skipped or late obligations.
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Friday, February 17, 2012
Nanoparticles in food, vitamins could harm human health, researchers warn
ScienceDaily (Feb. 16, 2012) ? Billions of engineered nanoparticles in foods and pharmaceuticals are ingested by humans daily, and new Cornell research warns they may be more harmful to health than previously thought.
A research collaboration led by Michael Shuler, the Samuel B. Eckert Professor of Chemical Engineering and the James and Marsha McCormick Chair of Biomedical Engineering, studied how large doses of polystyrene nanoparticles -- a common, FDA-approved material found in substances from food additives to vitamins -- affected how well chickens absorbed iron, an essential nutrient, into their cells.
The results were reported online Feb. 12 in the journal Nature Nanotechnology.
According to the study, high-intensity, short-term exposure to the particles initially blocked iron absorption, whereas longer-term exposure caused intestinal cell structures to change, allowing for a compensating uptick in iron absorption.
The researchers tested both acute and chronic nanoparticle exposure using human gut cells in petri dishes as well as live chickens and reported matching results. They chose chickens because these animals absorb iron into their bodies similarly to humans, and they are also similarly sensitive to micronutrient deficiencies, explained Gretchen Mahler, Ph.D. '08, the paper's first author and former Cornell graduate student and postdoctoral associate.
The researchers used commercially available, 50-nanometer polystyrene carboxylated particles that are generally considered safe for human consumption. They found that following acute exposure, a few minutes to a few hours after consumption, both the absorption of iron in the in vitro cells and the chickens decreased.
But following exposure of 2 milligrams per kilogram for two weeks -- a slower, more chronic intake -- the structure of the intestinal villi began to change and increase in surface area. This was an effective physiological remodeling that led to increased iron absorption.
"This was a physiological response that was unexpected," Mahler said.
Shuler noted that in some sense this intestinal villi remodeling was positive because it shows the body adapts to challenges. But it serves to underscore how such particles, which have been widely studied and considered safe, cause barely detectable changes that could lead to, for example, over-absorption of other, harmful compounds.
Human exposure to nanoparticles is only increasing, Shuler continued.
"Nanoparticles are entering our environment in many different ways," Shuler said. "We have some assurance that at a gross level they are not harmful, but there may be more subtle effects that we need to worry about."
The paper included Cornell co-authors Mandy Esch, a research associate in biomedical engineering; Elad Tako, a research associate at the Robert W. Holley Center for Agriculture and Health; Teresa Southard, assistant professor of biomedical sciences; Shivaun Archer, senior lecturer in biomedical engineering; and Raymond Glahn, senior scientist with the USDA Agricultural Research Service and courtesy associate professor in the Department of Food Science. The work was supported by the National Science Foundation; New York State Office of Science, Technology and Academic Research; Army Corp of Engineers; and U.S. Department of Agriculture.
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The above story is reprinted from materials provided by Cornell University, via Newswise. The original article was written by Anne Ju.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Gretchen J. Mahler, Mandy B. Esch, Elad Tako, Teresa L. Southard, Shivaun D. Archer, Raymond P. Glahn, Michael L. Shuler. Oral exposure to polystyrene nanoparticles affects iron absorption. Nature Nanotechnology, 2012; DOI: 10.1038/nnano.2012.3
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://www.sciencedaily.com/releases/2012/02/120216185408.htm
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Obama campaign, Democrats raise $29.1 million in January (Reuters)
[unable to retrieve full-text content]Reuters - President Barack Obama's re-election campaign and its Democratic allies raised a combined $29.1 million in January, accelerating their fundraising pace as the White House race draws closer.
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Thursday, February 16, 2012
Drinking alcohol shrinks critical brain regions in genetically vulnerable mice
ScienceDaily (Feb. 15, 2012) ? Brain scans of two strains of mice imbibing significant quantities of alcohol reveal serious shrinkage in some brain regions -- but only in mice lacking a particular type of receptor for dopamine, the brain's "reward" chemical. The study, conducted at the U.S. Department of Energy's Brookhaven National Laboratory and published in the May 2012 issue of Alcoholism: Clinical and Experimental Research, now online, provides new evidence that these dopamine receptors, known as DRD2, may play a protective role against alcohol-induced brain damage.
"This study clearly demonstrates the interplay of genetic and environmental factors in determining the damaging effects of alcohol on the brain, and builds upon our previous findings suggesting a protective role of dopamine D2 receptors against alcohol's addictive effects," said study author Foteini Delis, a neuroanatomist with the Behavioral Neuropharmacology and Neuroimaging Lab at Brookhaven, which is funded through the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Coauthor and Brookhaven/NIAA neuroscientist Peter Thanos stated that, "These studies should help us better understand the role of genetic variability in alcoholism and alcohol-induced brain damage in people, and point the way to more effective prevention and treatment strategies."
The current study specifically explored how alcohol consumption affects brain volume -- overall and region-by-region -- in normal mice and a strain of mice that lack the gene for dopamine D2 receptors. Half of each group drank plain water while the other half drank a 20 percent ethanol solution for six months. Then scientists performed magnetic resonance imaging (MRI) scans on all the mice and compared the scans of those drinking alcohol with those from the water drinkers in each group.
The scans showed that chronic alcohol drinking induced significant overall brain atrophy and specific shrinkage of the cerebral cortex and thalamus in the mice that lacked dopamine D2 receptors, but not in mice with normal receptor levels. Mice in both groups drank the same amount of alcohol.
"This pattern of brain damage mimics a unique aspect of brain pathology observed in human alcoholics, so this research extends the validity of using these mice as a model for studying human alcoholism," Thanos said.
In humans, these brain regions are critically important for processing speech, sensory information, and motor signals, and for forming long-term memories. So this research helps explain why alcohol damage can be so widespread and detrimental.
"The fact that only mice that lacked dopamine D2 receptors experienced brain damage in this study suggests that DRD2 may be protective against brain atrophy from chronic alcohol exposure," Thanos said. "Conversely, the findings imply that lower-than-normal levels of DRD2 may make individuals more vulnerable to the damaging effects of alcohol."
That would in effect deal people with low DRD2 levels a double whammy of alcohol vulnerability: Previous studies conducted by Thanos and collaborators suggest that individuals with low DRD2 levels may be more susceptible to alcohol's addictive effects.
"The increased addictive liability and the potentially devastating increased susceptibility to alcohol toxicity resulting from low DRD2 levels make it clear that the dopamine system is an important target for further research in the search for better understanding and treatment of alcoholism," Thanos said.
This research was supported by NIAAA.
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The above story is reprinted from materials provided by DOE/Brookhaven National Laboratory.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Foteini Delis, Helene Benveniste, Michalis Xenos, David Grandy, Gene-Jack Wang, Nora D. Volkow, Panayotis K. Thanos. Loss of Dopamine D2 Receptors Induces Atrophy in the Temporal and Parietal Cortices and the Caudal Thalamus of Ethanol-Consuming Mice. Alcoholism: Clinical and Experimental Research, 2011; DOI: 10.1111/j.1530-0277.2011.01667.x
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/eirNMAekz0M/120215190018.htm
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GOP critics hit Obama's $3.8 trillion budget (AP)
WASHINGTON ? Treasury Secretary Timothy Geithner told Congress Tuesday that the president's new $3.8 trillion spending plan would impose new taxes on only 2 percent of the nation's wealthiest families and the alternative would be to seek more painful cuts in other government programs such as defense, Social Security and Medicare.
Geithner defended the new budget plan in the face of intense attacks from GOP members of the Senate Finance Committee. Republican Sen. Orrin Hatch of Utah told Geithner that the administration's spending plan would give the country a "permanently larger, European-inspired government."
But Geithner said deeper spending cuts now would damage economic growth and push more Americans into poverty at a time when the economy is still struggling to recover from a deep recession.
Geithner told the committee that the administration hopes to send Congress next week a framework for making changes in the country's corporate tax structure.
He said the administration would not offer detailed legislative language but rather broad principles for corporate tax reform. He said the administration would propose eliminating a number of current business tax breaks in an effort to lower the corporate tax rate.
The nominal U.S. corporate tax rate is 35 percent, the highest in the world after Japan, but few companies pay that much after taking various deductions.
Obama has proposed lowering that tax rate but has not said by how much it should be lowered. The president has also proposed ending tax breaks for U.S. companies moving jobs or profits to foreign countries while suggesting tax breaks for businesses that move jobs back to the United States.
Geithner did not offer any hints about what recommendations the administration will make on corporate rates in its submission to Congress.
Congress may put off the tough decisions on the budget until after the November elections, but the spending document will certainly be used as a campaign document for Obama and a key target for Republicans running against Democrats.
Republican Mitt Romney, who is campaigning for the GOP nomination to challenge Obama in the fall, called the budget Obama released Monday "an insult to the American taxpayer." GOP candidates Rick Santorum, Newt Gingrich and Ron Paul are all advocating bigger spending cuts to control the deficits, and all the GOP candidates oppose Obama's tax increases.
"The president's budget is a gloomy reflection of his failed policies of the past, not a bold plan for America's future," House Speaker John Boehner, R-Ohio, said Monday after the budget was released. "The president offered a collection of rehashes, gimmicks and tax increases that will make our economy worse."
Republicans are arguing for deeper spending cuts and a frontal assault on the biggest drivers of the deficit, the soaring costs of Medicare and Medicaid, whose already sizable costs are projected to double in future years as baby boomers retire.
Rep. Paul Ryan, R-Wis., chairman of the House Budget Committee, said Monday that he expected the Republican-controlled House would in coming weeks pass an alternative to the Obama budget that would gain control of the deficit, not by raising taxes but by curtailing Medicare and Medicaid.
"President Obama's irresponsible budget is a recipe for a debt crisis and the decline of America," Ryan said.
Obama's cuts in Medicare and Medicaid avoid cuts in benefits and instead make modest trims in payments to health care providers. In contrast, the Republican House last year approved Ryan's plan, which would essentially transform Medicare into a voucher system in which future seniors would get a fixed amount to buy medical insurance.
The Obama budget proposes spending $3.8 trillion in the 2013 budget year, which begins Oct. 1. It would achieve $4 trillion in deficit cuts in part through restraining the growth of many government programs, adhering to the agreement Congress approved in August for spending caps to achieve $900 billion in deficit reduction over a decade.
Obama's plan also proposes additional deficit reduction in order to avoid $1.2 trillion in across-the-board cuts scheduled to take effect next January.
But the president relies on $1.5 trillion in tax increases, mainly by allowing the Bush-era tax cuts to expire on families making more than $250,000 per year, imposing additional taxes on those making more than $1 million per year and eliminating various corporate tax breaks.
The tax increases all have been rejected by Republicans.
With both parties holding entrenched positions, it is very likely that no solution will be found before the November elections, with both sides preferring to use the debate to score political points.
If that occurs, Congress will probably be back in Washington after the November elections for a lame-duck session to resolve the battle over taxes and spending cuts.
Lawmakers are facing end-of-the-year deadlines when the Bush-era tax cuts on all taxpayers expire and across-the-board spending cuts will go into effect if lawmakers can't agree on $1.2 trillion in further deficit reduction over the next decade.
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